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IntroductionAntibiotic is important in defending disease make bacteria, pathogens and virus. Antibiotic defense or drug or antimicrobial resistance means the ability of microorganism to defend against the effect caused by antibiotic. harmonise to World Health Organization (2006), aquaculture involves cultivating aquatic animals and plants in a dependant environment. Chatterjee and Haldar (2012) reported that almost one-third of the total fish supply in the world is contributed by aquaculture for domestic consumption. Annually, The State of World Fisheries and Aquaculture has reported that aquaculture possesses an median(a) increase of 8.3%. The development of antibiotic resistance bacteria is due to the role of antibiotic in the feeds and immersion therapy (McPhearson, DePoala, Zywno, Motes Jr, & Guarino, 1991). The examples of antibiotic resistance bacteria that goat be ensnare in aquaculture wet discharge are Aeromonas hydrophila, Edwardsiella tarda, vibrio vulnificus and Plesiomonas shigelloides (Hernandez Serrano, 2005). When human handle and consume these aquatic organisms, they may be assailable to some diseases which results in public health issue. Vibrio vulnificusVibrio vulnificus (V. vulnificus) is a Gram-negative, motile and rod-shaped bacterium that lives freely in estuarine, marine and fresh weewee environment associated with aquatic animals. It can be isolated from water, sediments and seafood from seawater and aquaculture water (Jones & Oliver, 2009). Higher concentration of V. vulnificus can be found during summer when water temperature increases (Centers for Disease Control and Prevention, 2013). Hence, V. vulnificus is also termed as halophiles as they are found in salty and high temperature environme... ...d-development-of-rapid-and-accurate-identification-methods-2155-9910.S1-002.pdfHernandez Serrano, P. (2005). Responsible use of antibiotics in aquaculture. Retrieved physical body ftp//ftp.fao.org/docrep/fao/009/a0282e/a0282e0 0.pdfMcPhearson, R. M., DePoala, A., Zywno, S. R., Motes Jr., M. L., & Guarino, A. M. (1991). Antibiotic resistance in gram-negative bacteria from urbane catfish and aquaculture ponds. Aquaculture, 99, 203-211.Morris, J. G. (2013). Vibrio vulnificus infections. Retrieved from http//www.uptodate.com/contents/vibrio-vulnificus-infectionsTodar, K. (2009). The microbial world. Retrieved from http//textbookofbacteriology.net/themicrobialworld/homepage.htmlWorld Health Organization. (2006). germicide use in aquaculture and antimicrobial resistance. Retrieved from http//www.who.int/topics/foodborne_diseases/aquaculture_rep_13_16june2006%20.pdf